Premium Marine & Herbal Ingredients from Thailand

Docosahexaenoic acid (DHA) is the predominant omega-3 fatty acid in the brain and retina, comprising >90% of brain omega-3s. High-DHA tuna head oil (4:1+ DHA:EPA ratio) provides a concentrated, cost-effective source for applications targeting neural development, cognitive maintenance, and prenatal health.

Key Clinical Findings:

A meta-analysis of 15 randomized controlled trials (n=1,674) concluded that DHA supplementation significantly improved cognitive performance in healthy adults, with effect sizes of 0.3–0.5 SD for memory and processing speed. For prenatal applications, systematic reviews show that maternal DHA intake of ≥200mg/day is associated with improved infant visual acuity and neurodevelopmental outcomes at 12–18 months.

DHA's mechanism involves incorporation into neuronal membrane phospholipids, modulation of neuroinflammation via PPAR-gamma pathways, and enhancement of synaptic plasticity. The 4:1 DHA:EPA ratio in tuna head oil matches the brain's natural lipid profile more closely than standard fish oils (typically 1:1–2:1), making it an efficient substrate for neural tissue incorporation.

Compared to algal DHA ($60–100/kg) and krill oil ($80–120/kg), tuna head oil delivers comparable DHA content at $25–40/kg — a 50–70% cost reduction without sacrificing bioavailability or purity.

Marine collagen peptides (MW 2,000–5,000 Da) demonstrate significantly higher intestinal absorption rates than bovine or porcine collagen due to their lower molecular weight and unique amino acid composition rich in glycine, proline, and hydroxyproline.

Key Clinical Findings:

A 2020 systematic review of 19 clinical trials including over 1,125 participants found that oral marine collagen peptide intake (2.5–10g/day for 8–24 weeks) significantly improved skin hydration by 12–28%, skin elasticity by 8–15%, and reduced wrinkle depth by 15–27% compared to placebo. The effects were dose-dependent with optimal results at ≥5g/day.

For joint health, a 12-week RCT (n=147) demonstrated that marine collagen peptide supplementation (10g/day) reduced joint pain scores by 43% during activity in athletes, with significant improvements in joint mobility and recovery time. The mechanism involves transport of hydroxyproline-containing dipeptides (Pro-Hyp, Hyp-Gly) to cartilage tissue, stimulating type II collagen synthesis.

Tuna-derived collagen offers a distinct amino acid profile from cold-water fish species, with higher threonine and serine content. Year-round tropical sourcing eliminates the 3–4 month seasonal gaps common with North Atlantic and Antarctic fisheries.

Curcuma longa L. is one of the most extensively studied botanicals, with over 12,000 PubMed-indexed publications. Thai turmeric (Curcuma longa grown in Thailand) exhibits a distinct chemotype characterized by higher bisdemethoxycurcumin (BDMC) content and a unique sesquiterpene profile compared to Indian varieties — a commercially underexploited differentiation.

Key Clinical Findings:

Curcumin's anti-inflammatory mechanism is well-characterized: it downregulates NF-κB activation by binding directly to IKKβ and p300/CBP, reducing production of TNF-α, IL-1β, and IL-6. A 2017 meta-analysis of 24 RCTs (n=1,753) found that curcumin supplementation (500–1,500mg/day) significantly reduced CRP by 60% (SMD -0.60, 95% CI -0.88 to -0.32) and TNF-α by 67% compared to placebo.

BDMC (bisdemethoxycurcumin), which is naturally elevated in the Thai chemotype, has demonstrated distinct pharmacological properties. In vitro studies show BDMC exhibits 2.3-fold higher bioavailability than curcumin in Caco-2 cell models and modulates different metabolic pathways — including selective PPAR-gamma activation and enhanced Nrf2-mediated antioxidant response. This chemotype difference means Thai turmeric extract is not simply a substitute for Indian-origin turmeric but a differentiated material with distinct formulation characteristics.

Our USDA Organic certified supply chain ensures full traceability from contracted Thai farms through GMP-certified extraction, and standardized to ≥95% curcuminoids by HPLC with guaranteed BDMC fraction.

Cartilage-derived peptides are well-established in joint health applications, but the market relies almost exclusively on bovine and chicken sources. Tuna cartilage represents an untapped marine alternative with distinct biochemical properties, including a unique glycosaminoglycan (GAG) profile.

Why Marine Cartilage?

Tuna cartilage contains a different collagen type distribution than terrestrial sources, with higher proportions of type II collagen and chondroitin sulfate relative to the matrix. Studies on marine-derived cartilage extracts suggest they stimulate chondrocyte proliferation and reduce MMP-mediated cartilage degradation more effectively than bovine sources at equivalent doses.

Our Phase 2 development program includes regulatory clearance through the Thai FDA (อย.) notification pathway. For B2B ingredient supply, the material is available for formulation development and clinical validation partnerships.